MICROBIOLOGY
MICROBIOLOGY
MICROBIOLOGY
See Also
MORPHOLOGY AND CULTURE CHARACTERISTICS OF PROTEUS VULGARIS (PR. VULGARIS) | BACTERIOLOGY NOTESClassification, Identification, and Clinical Significance of Proteus, Providencia, and MorganellaProteus Infections Workup: Laboratory Studies, Imaging StudiesEscherichia, Klebsiella, Enterobacter, Serratia, Citrobacter, and Proteus- Aerobic, Gram-negative, urease-splitting rod. It is a non-lactose fermenter, indole-negative, oxidase-negative but catalase- and nitrate-positive.
- "Swarms" on moist agar (many flagella per organism, see video as an example).
- The second most commonly isolated Enterobacteriaceae after E. coli in many series.
- Most common species: P. mirabilis (indole negative) causes 90% of infections.
- Other Proteus spp. are indole positive, e.g., P. vulgaris and P. penneri.
- Proteus rettgari now a member of Providencia spp., properly Providencia rettgari, often a highly resistant organism.
- It can raise urine pH due to urea-splitting activity.
- P. mirabilis is usually inherently resistant to tetracycline, colistin and nitrofurantoin, while 10-20% are resistant to ampicillin or cephalexin. P. vulgaris usually resistant to ampicillin or cephalexin/cefazolin.
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Last updated: May 30, 2021
Citation
Auwaerter, Paul. "Proteus Species." Johns Hopkins ABX Guide, The Johns Hopkins University, 2021. Johns Hopkins Guides, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540454/all/Proteus_species.
Auwaerter P. Proteus species. Johns Hopkins ABX Guide. The Johns Hopkins University; 2021. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540454/all/Proteus_species. Accessed March 28, 2024.
Auwaerter, P. (2021). Proteus species. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540454/all/Proteus_species
Auwaerter P. Proteus Species [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2021. [cited 2024 March 28]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540454/all/Proteus_species.
* Article titles in AMA citation format should be in sentence-case
TY - ELECT1 - Proteus speciesID - 540454A1 - Auwaerter,Paul,M.D.Y1 - 2021/05/30/BT - Johns Hopkins ABX GuideUR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540454/all/Proteus_speciesPB - The Johns Hopkins UniversityDB - Johns Hopkins GuidesDP - Unbound MedicineER -
FAQs
If a patient has a more severe condition or is in an inpatient setting, they may begin antibiotic therapy via intravenous administration of either ceftriaxone, gentamycin, fluoroquinolone, gentamycin plus ampicillin, or aztreonam until fever resolves.
What antibiotic treats Proteus species? ›
If a patient has a more severe condition or is in an inpatient setting, they may begin antibiotic therapy via intravenous administration of either ceftriaxone, gentamycin, fluoroquinolone, gentamycin plus ampicillin, or aztreonam until fever resolves.
What is the drug of choice for Proteus? ›
For hospitalized patients, therapy consists of parenteral (or oral once the oral route is available) ceftriaxone, quinolone, gentamicin (plus ampicillin), or aztreonam until defervescence. Then, an oral quinolone, cephalosporin, or TMP/SMZ for 14 days may be added to complete treatment.
Does Macrobid work for Proteus mirabilis? ›
Aerobic And Facultative Gram-Negative Microorganisms
Nitrofurantoin is not active against most strains of Proteus species or Serratia species. It has no activity against Pseudomonas species.
Does TMP SMX cover Proteus? ›
Trimethoprim-sulfamethoxazole is active against many Enterobacteriaceae, including Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis, accounting for its widespread use in those with UTIs. In the United States, it has been the drug of choice for empirical therapy for uncomplicated UTIs in women.
What is the first line antibiotic for Proteus mirabilis? ›
P mirabilis is likely to be sensitive to ampicillin; broad-spectrum penicillins (eg, ticarcillin, piperacillin); first-, second-, and third-generation cephalosporins; imipenem; and aztreonam.
Does Bactrim cover Proteus? ›
For the treatment of urinary tract infections due to susceptible strains of the following organisms: Escherichia coli, Klebsiella species, Enterobacter species, Morganella morganii, Proteus mirabilis and Proteus vulgaris.
How do you treat Proteus ABX? ›
Carbapenem antibiotic is the choice for Proteus in severe infections due to concerns for inducible Amp-C resistance. Most commonly used fluoroquinolone, especially for UTI.
Does Keflex cover Proteus mirabilis? ›
KEFLEX is indicated for the treatment of genitourinary tract infections, including acute prostatitis, caused by susceptible isolates of Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae.
Is Augmentin good for Proteus? ›
Listed dosages may need to be adjusted for renal dysfunction. Proteus mirabilis: Ceftin (cefuroxime oral) 250-500mg orally twice daily. Augmentin 875/125 mg orally twice daily.
5 medications found for 'proteus mirabilis urinary tract infection'
- cipro xr 1,000 mg tablet,extended releaseOn LabelRXReviews.
- ciprofloxacin er 1,000 mg tablet,extended release 24hr mphaseOn LabelRXReviews.
- ciprofloxacin er tablet, extended release multiphase 24 hr (tablet, hr)On LabelRXReviews.
A study in Brazil found that effective antibiotics against Proteus mirabilis isolated from patients with community-acquired urinary tract infection were as follows: sulfamethoxazole (78.1%); naphthalinic acid and gentamicin (94.5%); norfloxacin and ciprofloxacin (96.7%); amikacin and amoxicillin + clavulanic acid (99.5 ...
Does Cipro cover Proteus mirabilis? ›
All tested strains of P. mirabilis and P. vulgaris were susceptible to ciprofloxacin.
Is Keflex effective against Proteus? ›
Cephalexin is commonly utilized in the treatment of urinary tract infections, respiratory infections, otitis media, bone infections caused by Staphylococcus aureus or Proteus mirabilis, and skin and soft tissue infections primarily caused by S aureus or Streptococcus pyogenes.
What antibiotics are used for Proteus mirabilis pneumonia? ›
P. mirabilis is generally resistant to antibiotic such as ceftazidime, cefepime, and fluoroquinolones. Therefore, for ESBL positive microorganisms carbapenems should be the drug of the choice.
Does Rocephin treat Proteus mirabilis? ›
Rocephin is indicated for the treatment of the following infections when caused by sus- ceptible organisms: LOWER RESPIRATORY TRACT INFECTIONS caused by Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Escherichia coli, Enterobacter aerogenes, ...
Is amoxicillin effective against Proteus? ›
A study in Brazil found that effective antibiotics against Proteus mirabilis isolated from patients with community-acquired urinary tract infection were as follows: sulfamethoxazole (78.1%); naphthalinic acid and gentamicin (94.5%); norfloxacin and ciprofloxacin (96.7%); amikacin and amoxicillin + clavulanic acid (99.5 ...
Does Cipro treat Proteus? ›
It has been shown that ceftazidime and ciprofloxacin at concentrations equal to 1/4, 1/2 and 1 times their MIC values for particular Proteus spp. strains decrease their ability to form biofilms.
What medication is used for Proteus mirabilis UTI? ›
5 medications found for 'proteus mirabilis urinary tract infection'
- cipro xr 1,000 mg tablet,extended releaseOn LabelRXReviews.
- ciprofloxacin er 1,000 mg tablet,extended release 24hr mphaseOn LabelRXReviews.
- ciprofloxacin er tablet, extended release multiphase 24 hr (tablet, hr)On LabelRXReviews.
All tested strains of P. mirabilis and P. vulgaris were susceptible to ciprofloxacin.
